Effects of Cig. Mentholation on Brain Nicotine Accumulation During Smoking
(Winston Salem office only)
The purpose of this study is to examine the rate that nicotine accumulates in your brain when smoking a menthol cigarette compared to a non-menthol cigarette.
This study consists of one physical screen and five study sessions over a three- to four-week period. The physical exam will take approximately 2 to 2 ½ hours and includes a drug screen. If you test positive for illegal drugs, you will not be eligible to participate. If the physical screen confirms you are a good match for this study, you will be asked to return to the center for five study sessions. The study sessions will involve the following types of visits: Smoking Evaluation Sessions and Positron Emission Tomography (PET) Sessions.
There will be three Smoking Evaluation Sessions -- each lasting approximately 1 ½ to 2 hours. During these sessions, you may be asked to smoke one of your own cigarettes shortly after arriving for your visit. Your blood pressure, heart rate, and the CO (carbon monoxide) in your exhaled breath will be measured. You will also smoke cigarettes through a smoking device that records information about your smoking habits and be asked to fill out questionnaires. At the end of the first session, you will be given study cigarettes to smoke for the next week or so. You will also be asked to smoke several puffs of a cigarette from a smoking delivery system that controls how much smoke you inhale. This will be the same device you smoke from at the PET sessions.
There will also be two Positron Emission Tomography (PET) Sessions -- each lasting approximately 2 to 2 ½ hours. PET scans are used to show chemical and functional changes within your body. During these scans, you will be asked to lie on an imaging table and remain still for about 45 minutes while the images are being taken. Blood samples will be taken to measure the amount of nicotine and cotinine (a byproduct of nicotine) in your blood. Your blood pressure, heart rate, and the CO in your exhaled breath will also be measured.
Your entire participation in this study will last approximately three to four weeks. If you complete all study visits and study requirements, you will be compensated up to $500. You will receive a check in the mail after you complete study participation. Please allow four to six weeks for your payment to be processed.